Prostate Cancer Risk May be Reduced with Lignans

Two studies cited below, both discovered that men with higher serum levels of lignan have reduced rates of prostate cancer.

There are two main types of androgens in men and they are testosterone and dihydrotestosterone (DHT).

DHT is a more potent and potentially more dangerous hormone than testosterone. DHT is critical in the early stages of life for development of the penis, scrotum and testicles but later in life its accumulation can actually cause prostate cancer, balding in men, and cardiovascular inflammation.

The enzyme 5-alpha-reductase synthesizes DHT in the prostate, adrenal glands, testicles, and hair follicles. DHT gets stored in the prostate and gets stored in hair follicles. Lignans prevent the metabolic errant conversion of testosterone into DHT by reducing the amount of 5a reductase enzyme in the body effectively reducing DHT.

Over time the lignans will reduce the amount of DHT in hair follicles and you may see additional hair growth.  Hair follicles are not dead.  Most balding is due to atrophy in hair follicles because of DHT. Also over time DHT is reduced in the prostate and men have reported reduced urination frequency and more urine flow. Several studies show a reduced rate of prostate cancer in men with higher amounts of lignan as measured from plasma levels.

Lignans and melatonin both block aromatase enzyme. Aromatase enzyme is responsible for converting testosterone into estrogen. Many body builders use lignans to block aromatase enzyme as a way of boosting testosterone via preventing testosterone loss in the conversion.

A case-control study conducted in Scotland found that higher serum enterolactone concentrations were associated with a lower risk of prostate cancer Heald CL, Ritchie MR, Bolton-Smith C, Morton MS, Alexander FE. Phyto-oestrogens and risk of prostate cancer in Scottish men. Br J Nutr. 2007;98(2):388-396. (PubMed)

Flaxseed SDG may have a therapeutic role in lupus nephritis. (Clark W. et al Lupus, 9(6): 429, 2000) Asian men have a much lower incidence of prostate cancer and possibly of benign prostatic hyperplasia (BPH) than Western counterparts. Vegetarian men have a lower incidence of prostate cancer than omnivorous males. Plant lignans give rise to the mammalian lignans, enterodiol and enterolactone; the richest source is linseed (flaxseed). In addition to their oestrogenic activity, these plant compounds can interfere with steroid metabolism and bioavailability, and also inhibit enzymes, such as tyrosine kinase and topoisomerase, which are crucial to cellular proliferation and hence may contribute to lower incidences of prostate cancer. (Eur Urol, 35(5-6): 377, 1999)


"My name is Mack E., I am 71 years old,
The males in my family seems to be predisposed to prostate cancer and other prostate problems, I was diagnosed with BPH approx 6 years ago which elevates PSA. My attending physician had me try everything including herbal remedies but with little or no relief. A friend of mine mentioned Flaxseed Lignans and the results of my internet search led me to Lignans for Life. I purchased a bottle of Flaxseed Lignan capsules and after one bottle, I have nothing but the highest praise about this product; I would recommend it without reservations.
It has changed my life....I've ordered 4 more bottles so I will not run low.

“My husband, Gordon has had a lot of problems urinating & has been on saw palmetto for two years. I started him on flaxseed hull lignans a month ago. In questioning him this past week, I found out that he only gets up once a night now. When urinating he does not have nearly the problems beginning, he goes much less often and he passes a lot more urine with each trip. thanks for a great product!" -Sincerely Margo H.

The information provided in this article is for informational purposes only. This information should not be construed as medical advice. It is up to the individual reading this to get expert medical advice and not rely on this information for diagnosis, treatment, prevention or attempting to cure any disease.

One More Study published on the US government web site National Institute of Health

Flaxseed-derived enterolactone is inversely associated with tumor cell proliferation in men with localized prostate cancer." Department of Nutrition Sciences, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA. read the whole study on the US government website national institute of health Pub med site. "In conclusion, flaxseed-derived enterolignans may hinder cancer cell proliferation via VEGF-associated pathways.”